Interleukin-22 ameliorates liver fibrogenesis by attenuating hepatic stellate cell activation and downregulating the levels of inflammatory cytokines

Figure 8 Recombinant interleukin-22 decreased the production of tumor necrosis factor-α, interleukin-6 and interleukin-1β. The levels of tumor necrosis factor (TNF)-α (A), interleukin (IL)-6 (B) and IL-1β (C) circulating proteins were measured by enzyme-linked immunosorbent assay, and relative hepatic expression of mRNA was investigated by reverse transcription polymerase chain reaction in the recombinant IL (rmIL)-22 group and the carrier group (D-F), ^bP < 0.01 vs the carrier group. Data are mean ± SD (n = 8).