Interleukin-22 ameliorates liver fibrogenesis by attenuating hepatic stellate cell activation and downregulating the levels of inflammatory cytokines

Figure 4 Elevated expression of interleukin-22, interleukin-17 and interferon-γ mRNA in mice with hepatic fibrosis. A-C: The results of statistical analyses for the alterations in interleukin (IL)-22, IL-17 and interferon (IFN)-γ mRNA in different subgroups; D-F: A positive correlation was found between T helper (Th)-22 cells and IL-22 mRNA, Th17 cells and IL-17A mRNA, Th1 cells and IFN-γ mRNA in the fibrosis group at week 4. ^bP < 0.01 vs the control subgroups sacrificed at the same time point; ^dP < 0.01 vs the other fibrosis subgroups. Data are mean ± SD (n = 8-10).