Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response

Figure 3 Comparison of LC3β expression, determined by immunohistochemistry in HBV^Pos and HBV^Neg liver tissue microarrays. Immunohistochemistry was performed as described in Materials and Methods. H-scores were derived from semi-quantitative assessments of both staining intensity (scale 0-3) and the percentage of positive cells (0%-100%) and, when multiplied, generate a score ranging from 0 to 300. A: Representative image of tissue core from HBV^Neg liver showing low expression of LC3β (H-score of 50); B: HBV^Pos liver tissue showing higher expression of LC3β (H-score of 150); C: The bar graphs show expression levels (H-score) of LC3β in HBV^Pos and HBV^Neg liver tissue microarrays. The bars represent the mean ± SEM. ^aP < 0.001 vs the normal HBV^Neg. HBV: Hepatitis B virus; HCV: Hepatitis C virus.