New drug delivery system for liver sinusoidal endothelial cells for ischemia-reperfusion injury

doi:10.3748/wjg.v21.i45.12778

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 7, 2015; 21(45): 12778-12786
Published online Dec 7, 2015. doi: 10.3748/wjg.v21.i45.12778

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Figure 3 Histological findings. A: HE staining In the control (a), HA (b), and S1P group (c) histologic examination revealed vacuolation of the hepatocytes and loss of palisade arrangement after 120 min of reperfusion. These findings were not observed in the HA-S1P group (d). (hematoxylin-eosin stain, magnification × 200); B: TUNEL (TdT-mediated dUTP-biotin nick end labeling) assay of the liver tissue and (C) the ratio of TUNEL-positive/total hepatocytes In the control (a), HA (b), and S1P groups (c), TUNEL-positive cells were observed in zone 1 after 120 min of reperfusion. These findings were not observed in the HA-S1P group (d). ^bP < 0.01 vs the control, HA, and S1P groups. HA: Hyaluronic acid; S1P: Sphingosine 1-phosphate.

Citation: Sano N, Tamura T, Toriyabe N, Nowatari T, Nakayama K, Tanoi T, Murata S, Sakurai Y, Hyodo M, Fukunaga K, Harashima H, Ohkohchi N. New drug delivery system for liver sinusoidal endothelial cells for ischemia-reperfusion injury. World J Gastroenterol 2015; 21(45): 12778-12786
URL: https://www.wjgnet.com/1007-9327/full/v21/i45/12778.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i45.12778

Sano N, Tamura T, Toriyabe N, Nowatari T, Nakayama K, Tanoi T, Murata S, Sakurai Y, Hyodo M, Fukunaga K, Harashima H, Ohkohchi N. New drug delivery system for liver sinusoidal endothelial cells for ischemia-reperfusion injury. World J Gastroenterol 2015; 21(45): 12778-12786 [PMID: 26668502 DOI: 10.3748/wjg.v21.i45.12778]

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