MicroRNA in inflammatory bowel disease: Translational research and clinical implication

Table 4 Aberrant microRNA expression in human peripheral blood in Crohn’s disease

Status	Tissue type	Control	Aberrant microRNA expression	Ref.
Active CD	Peripheral blood, n = 14	Healthy	Decreased: miR-149* and plus-F1065	Wu et al[31], 2011
			Increased: miR-199a-5p, 340*, 362-3p, 532-3p and plus-E1271
	Peripheral blood, n = 46	Healthy	Increased: miR-16, 20a, 21, 30e, 93, 106a, 140, 192, 195, 484 and let-7b	Zahm et al[33], 2011
	Peripheral blood, n = 128	Healthy	Increased: miR-16, 23a, 29a, 106a, 107, 126, 191, 199a-5p, 200c, 362-3p and 532-3p	Paraskevi et al[32], 2012
Active and inactive CD	Peripheral blood, n = 18	Healthy	Decreased: miR-877	Iborra et al[25], 2013
			Increased: miR-16, 27a*, 140-3p, 140-5p and 195
Inactive CD	Peripheral blood, n = 5	Healthy	Decreased: miR-149*	Wu et al[31], 2011
			Increased: miR-340*
Active CD	Peripheral blood, n = 9	Inactive CD	Decreased: miR-18a, 128, 140-5p and 145	Iborra et al[25], 2013
			Increased: miR-188-5p and 877

CD: Crohn’s disease; UC: Ulcerative colitis.