Stage migration vs immunology: The lymph node count story in colon cancer

Table 5 Prognostic relevance of lymph node harvest in stage II and III colorectal cancers

First author	Year	n	N+	Insuff-rate	pT3/4	Endpoints	Cut off	Stage II	Stage III
Caplin	1998	377	NA	NA	NA	OS	> 6	Yes	No
Sarli	2005	1040	NA	NA	100%	5yOS	< 10	Yes	No
Wong	2005	21491	37%	NA	67%	OS	> 13	Yes	1
George	2006	3592	NA	79%	NA	5yOS	0-4; 5-10; > 10	Yes	Yes
Edler	2007	125	51%	87%	NA	OS	0-11 vs > 11	Yes	Yes1
Evans	2008	381	45.3%	47%1	82%	5yOS	≥ 9	Yes	2
Choi	2010	664	NA	NA	100%	DFS	> 20	Yes	No
Desolneux	2010	362	NA	NA	72.4%	OS	< 8 vs≥ 8 and < 12 vs≥ 12	Yes	No
Ogino	2010	716	38%	63%1	68.3%	CsS/OS	0-3 negative LN, 7-12 and > or = 13 negative LN	Yes	Yes
Fretwell	2010	351	48%	min 20%	95%	5yOS	≥ 9 (Dukes B); > 9 (Dukes C)	Yes	Yes
Wong	2011	8521	About 30%	32%	66%	CsS	medians: 4 vs 8 vs 10	Yes	No
Kotake	2011	16865	46%	24%1	100%	5yOS	< 10 vs > 27	Yes	Yes
Kritsanasakul	2012	533	43%	59.1%	82%	5yOS	≥ 12	Yes	1
Moro-Valdezate	2013	11662	39.7%	65%1	79.7%	5yOS/5yCsS	≥ 12	No	No
Zhang	2013	265	42.3%	75.1%	79.2%	OS	< 12	Yes	Yes
Onitilo	2013	1397	37%	26%	67%	OS	≥ 12	Yes	Yes
Duraker	2014	461	NA	51%	74%	CsS	≥ 12	Yes	No1

¹Survival analysis only in the nodal negative sub group (n = 1348);

²Based on cases with available survival data (n = 359). NA: No available data; 5yOS: 5 year overall survival; 5yDFS: 5 year disease-free survival; OS: Overall survival; CsS: Cancer specific survival; HR: Hazard rate; LN: Lymph node; PFS: Progression-free survival.