Stage migration vs immunology: The lymph node count story in colon cancer

Table 2 Prognostic relevance of lymph node harvest in stage II colon cancers

First author	Year	n	Insuff.-rate	pT3/4	Prognostic	Endpoints	Cut off	Survival
Swanson	2003	35787	60%	100%	Yes	5yOS	No cut off	linear increase of 5yOS-rate
Law	2003	115	NA	100%	Yes	5yOS, 5yDFS	≥ 7	5yOS: < 7LN 69% vs > 6LN 89%
Bui	2006	4531	NA	NA	Yes	OS	1-3 vs 10-36	HR = 0.6 (CI: 0.4-1.0), P = 0.03
Bilimoria	2008	142009	NA	59%	Yes	5yOS	≥ 12	HR = 0.75 (CI: 0.71-0.8), P < 0.0001
Maggard	2009	11263	NA	69%	Yes	5yOS	4 (T1) and 10 (T2)	T1: HR = 0.76 (CI: 0.641-0.902), P = 0.002
								T2: 0.853 (CI: 0.776-0.937), P = 0.001
Stocchi	2011	901	NA	100%	Yes	OS, DFS, CsS	≥ 12	< 12 LN: HR = 1.93 (1.27-2.94), P = 0.002
Sato	2011	1476	56%	100%	Yes	5yOS	> 12	ACT: improved 5yOS for LNs ≤ 12

¹Sub-group of the study collection. NA: No available data; 5yOS: 5 years overall survival; 5yDFS: 5 years disease-free survival; OS: Overall survival; CsS: Cancer specific survival; ACT: Adjuvant chemotherapy; LN: Lymph node.