Acute-on-chronic liver failure: Pathogenesis, prognostic factors and management

Table 2 Grades of acute-on-chronic liver failure according to the number of organ failure and the type of organ

No. ACLF
ACLF grade 1	Single- organ failure (coagulation, liver, circulation, lungs) in patients with sCr 1.5-1.9 mg/dL and/or grades 1-2 HE or braine failure with sCr range from 1.5-1.9 mg/dL
ACLF grade 2	Two organ failures
ACLF grade 3	Three or more organ failures

Data from the CANONIC study[12]. ACLF: Acute-on-chronic liver failure; OF: Organ failure.