Application of nucleoside analogues to liver transplant recipients with hepatitis B

doi:10.3748/wjg.v21.i42.12091

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 14, 2015; 21(42): 12091-12100
Published online Nov 14, 2015. doi: 10.3748/wjg.v21.i42.12091

Table 1 Structure, mechanism of action, and incidence of resistance of currently available nucleoside analogues[12,20,21]

Drug name	Structure	Mechanism of action	Incidence of drug resistance
LAM	Cytidine analogue	Premature chain termination	High
LDT	Thymidine analogue	Premature chain termination	High
ETV	Guanosine analogue	Inhibits priming RT	Low
ETV	Guanosine analogue	Inhibit negative and positive strand synthesis	Low
ADV	Adenosine analogue	Premature chain termination	High
TDF	Adenosine analogue	Inhibit negative strand synthesis	Unknown

ADV: Adefovir dipivoxil; ETV: Entecavir; HBV: Hepatitis B virus; LAM: Lamivudine; LDT: Telbivudine; NA: Nucleoside analogue; RT: Reverse transcriptase; TDF: Tenofovir.

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Citation: Song ZL, Cui YJ, Zheng WP, Teng DH, Zheng H. Application of nucleoside analogues to liver transplant recipients with hepatitis B. World J Gastroenterol 2015; 21(42): 12091-12100
URL: https://www.wjgnet.com/1007-9327/full/v21/i42/12091.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i42.12091

Song ZL, Cui YJ, Zheng WP, Teng DH, Zheng H. Application of nucleoside analogues to liver transplant recipients with hepatitis B. World J Gastroenterol 2015; 21(42): 12091-12100 [PMID: 26576094 DOI: 10.3748/wjg.v21.i42.12091]

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