Nanoparticles for targeted delivery of therapeutics and small interfering RNAs in hepatocellular carcinoma

Table 2 Summary of studied targeted nanoparticles used in vitro/in vivo for small interfering RNA delivery in hepatocellular carcinoma using different targeting moieties

Type of nanocarrier	Active moiety	Targeted receptor	Suggested Mechanism	Ref.
Lipid nanoparticle	TetR siRNA	-	-	[31]
Novel nonocarrier consisting of a silica core fused to liposomes (called protocell)	Model siRNA	SP94 protein and EPR	-	[64]
Galactose mediated trimethylchitosan cysteine NPs	VEGF-siRNA and Survivin shRNA-expression pDNA (iSUR-pDNA)	ASGPR	Silencing of tumor growth genes	[86]
A phospholipid-cholesterol nanocomplex	Pokemon siRNA	LDL receptor	Cell growth inhibition	[89]
A SPION called SilenceMag	Human VEGF siRNA	EGFR	Tumor growth inhibition	[95]
PEGylated Polyethyleneamine SPION	Survivin siRNA	Integrin	Induction of apoptosis	[114]
Virus-like nanoparticle of bacteriophage MS2	Anti-cyclin siRNA	Folic acid receptor, SP94, transferrin receptor	Induction of apoptosis	[142]
Lipid nanoparticle	Integrin b1 siRNA	integrin	Inhibition of proliferation and tumor cell death	[116]

SPION: Superparamagnetic iron oxide nanoparticle; siRNA: Small interfering RNA; LDL: Low-density lipoprotein; EPR: Enhanced permeation and retention; EGFR: Epidermal growth factor receptor; ASGPR: Asialoglycoprotein receptor.