Non-coding landscapes of colorectal cancer

Table 2 Functions of long non-coding RNAs deregulated in colorectal cancer

lncRNA	Oncogene/tumor suppressor	Biological process	Target	PMID
AK123657	Tumor suppressor	Cell proliferation, invasion		24809982
BANCR	Oncogene	Cell migration, EMT		25013510
BX648207	Tumor suppressor	Cell proliferation, invasion		24809982
BX649059	Tumor suppressor	Cell proliferation, invasion		24809982
CCAT1-L	Oncogene	MYC expression regulation	MYC-335	24662484
CCAT2	Oncogene	WNT signalling pathway activation	TCF7L2, MYC, miR-17-5p, miR-20a	23796952
CRNDE	Oncogene	Epigenetic remodelling of chromatin		19571010
H19	Oncogene	miR-675 precursor, cell proliferation, EMT, miRNA sponge	let-7	17237358, 19926638
HOTAIR	Oncogene	HOXD expression regulation, metastasis	HOXD10, PGR	24075995, 20393566
MALAT1	Oncogene	pre-mRNA metabolism, target gene expression regulator, tumor suppressor protein regulation, cell cycle progression, cell migration, MET	PSF, E2F1	17270048, 16878148, 18067128, 22078878, 22722759
mascRNA	Oncogene	Cell proliferation, invasion		21503572
N-BLR	Oncogene	Apoptosis, cell migration, invasion		http://dx.doi.org/10.1101/004796
PVT1	Oncogene	miRNAs precursor, cell proliferation, invasion		18194563, 25043044
TUSC7	Tumor suppressor	Cell proliferation, miRNA sponge	miR-211	23558749

For all lncRNAs are reported: (1) their function in CRC (oncogene, and tumor suppressor); (2) the biological processes they are involved in; (3) their validated targets; (4) bibliographic references reported as PubMed ID (PMID). LncRNA: Long non-coding RNA.