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Copyright ©The Author(s) 2015.
World J Gastroenterol. Nov 7, 2015; 21(41): 11709-11739
Published online Nov 7, 2015. doi: 10.3748/wjg.v21.i41.11709
Table 1 Functions of microRNAs deregulated in colorectal cancer
microRNAOncogene/tumor suppressorProcess in CRCTargetsPMID
Let-7Tumor suppressorCell proliferation, migration, invasion, metastasisKRAS, MMP11, PBX323167843, 21984339, 16651716
miR-1Tumor suppressorCell proliferation, invasion, migrationMET22179665
miR-16Tumor suppressorCell proliferationPTGS222049153
miR-17-92 clusterOncogeneAngiogenesis, proliferation, metastasisTSP-1, CTGF, PTEN, BCL2L11, E2F1, E2F2, E2F3, TGFBR2, CDKN1A, BIM19460962, 16878133, 22308110, 24212931, 21883694
miR-18aTumor suppressorCell proliferation, migrationCDC42, HNRNPA125379703, 24166503
miR-21OncogeneCell proliferation, migration, invasion, metastasis, stemnessPDCD4, CCL20, Cdc25A, TGFBR2, PTEN, RHOB, RASA122677902, 17968323, 22099878, 19826040, 22120473, 23788041, 23544170, 23174819, 22072622, 21872591, 25663768
miR-23bTumor suppressorCell migration, invasion, angiogenesisFZD7, MEKK1, PAK2, TGFBR2, RRAS2, PLAU, VEGF22109528
miR-31OncogeneCell proliferation, invasion, migrationCDKN2B, RASA121062447, 25202407, 23322774
miR-34Tumor suppressorMigration, invasion, metastasis, EMTIL6R, ZNF281, MET, SNAIL, CTNNB1, SLUG, ZEB124642471, 24185900, 23243217, 22134354
miR-101Tumor suppressorCell proliferation, motility, invasionEP4, PTGS222353936, 19133256
miR-103/miR-107OncogeneInvasion, migration, metastasisDAPK, KLF422593189
miR-106aOncogeneCell proliferation, migration, invasion, metastasisRB1, TGFBR223178825, 22912877
miR-126Tumor suppressorCell proliferation, migration, invasion, metastasis, angiogenesisPIK3R2, IRS1, CXCR4, VEGF18663744, 24312276, 24189753, 24653631, 23900443
miR-135aOncogeneCell proliferation, migration, invasionMTSS123017832
miR-135bOncogeneCell proliferation, invasionAPC, TGFBR2, DAPK118632633, 24735923
miR-143Tumor suppressorCell proliferation, metastasisKRAS, ERK5, MACC1, HK2, IGF1R, DNMT3A19137007, 16969504, 22533346, 22691140, 23574723, 19638978
miR-145Tumor suppressorCell proliferation, angiogenesisMYC, CDK6, E2F1, CCND2, p70S6K1, PAK421278451, 15944709, 19843336, 21917858, 22766504
miR-148aTumor suppressorCell proliferationBCL221455217
miR-155OncogeneCell proliferation, migration, invasion, chemoresistanceCLDN123588589, 23036199
miR-181aOncogeneCell proliferation, invasion, metastasis, EMTPTEN, WIF124685694, 24755295
miR-200cTumor suppressorCell proliferation, invasion, migration, EMT, metastasisZEB1, ETS1, FLT1, CDH1, VIM22735571, 22407310
miR-210OncogeneCell migration, invasionVMP124632577
miR-320aTumor suppressorCell proliferation, migration, invasion, metastasis, EMTCTNNB1, RAC1, NRP122459450, 24265291, 22134529
miR-372OncogeneCell proliferationTXNIP, LATS222660396, 22456107
miR-638Tumor suppressorCell invasion, migrationSOX2, TSPAN124885288, 25301729
miR-720OncogeneCell proliferation, invasion, migrationSTARD1325286763, 22660396