Calcium glycerophosphate preserves transepithelial integrity in the Caco-2 model of intestinal transport

doi:10.3748/wjg.v21.i30.9055

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 14, 2015; 21(30): 9055-9066
Published online Aug 14, 2015. doi: 10.3748/wjg.v21.i30.9055

Table 3 Rate of trans epithelial electrical resistance loss and mannitol flux during the first four hours (mannitol flux) or 10 h (trans epithelial electrical resistance) following cytokine stimulation

Treatment	Rate of TEER loss	Rate of mannitol flux
Treatment	% per hour	dpm per hour
Control	0.064 ± 0.38^b	28 ± 3^b
Cytokine	2.1 ± 0.31	54 ± 1
Cytokine + 1 mmol/L CGP	0.76 ± 0.24^b	4 ± 1^b
Cytokine + 100 μmol/L CGP	0.87 ± 0.32^b	10 ± 1^b
Cytokine + 10 μmol/L CGP	1.4 ± 0.28^b	13 ± 1^b
Cytokine + 1 μmol/L CGP	2.4 ± 0.34	16 ± 2^b

Calcium glycerophosphate (CGP) treatment reduced both parameters in a dose-dependent fashion.

^bP < 0.001, vs cytokine alone. Each value represents the results of three independent experiments. dpm represents disintegrations per unit time. Data is expressed as mean ± SE.

Citation: Datta P, Weis MT. Calcium glycerophosphate preserves transepithelial integrity in the Caco-2 model of intestinal transport. World J Gastroenterol 2015; 21(30): 9055-9066
URL: https://www.wjgnet.com/1007-9327/full/v21/i30/9055.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i30.9055