Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats

Figure 4 Effect of berberine on hepatic AMPK and p-AMPK protein expression. Western blot analyses of AMPK and p-AMPK protein in liver tissues of normal control rats, model rats and diabetic rats treated with berberine, AICAR or metformin. A, C: Representative blots for each group are shown; B: Each bar is expressed as AMPKD/β-actin and represents the mean ± SD (n = 8); D: Each bar is expressed as p-AMPK/β-actin and represents the mean ± SD (n = 8). ^bP < 0.01 vs the normal control group; ^dP < 0.01 vs the model group (by ANOVA).