Effect of endogenous cholecystokinin on the course of acute pancreatitis in rats

Figure 4 Representative immunohistochemical studies of the pancreas in the four different treatment groups on day 12 after induction of AP. A: The pancreas of AP-C rats showed strong α-SMA expression in the degenerative regions; In AP-S (G) and AP-R/S rats (J), α-SMA was only detected in pancreatic ducts. In AP-C rats, TNF-α (B) and IL-1β (C) were strongly expressed in inflammatory cells in the pancreas. In AP-R, AP-S and AP-R/S rats, TNF-α (E, H and K) and IL-1β (F, I and L) were not detected in the pancreas; D: Pancreatic rest (AP-R) markedly reduced α-SMA expression. Arrows in A, D, G and J indicate α-SMA expression in the pancreas. Arrows in B indicate TNF-α expression in the pancreas. Arrows in C indicate IL-1β expression in the pancreas. Original magnification × 50.