Berberine inhibits hepatic gluconeogenesis via the LKB1-AMPK-TORC2 signaling pathway in streptozotocin-induced diabetic rats

Table 1 Effects of berberine on plasma lipid profiles of diabetic rats (mean ± SD, n = 8)

Group	TG (mmol/L)	TC (mmol/L)	LDL-C (mmol/L)	HDL-C (mmol/L)
Normal	0.98 ± 0.15	3.74 ± 0.56	1.48 ± 0.18	2.68 ± 0.48
Model	2.7 ± 0.57b	6.66 ± 1.14b	4.26 ± 0.63b	1.14 ± 0.15b
Berberine	1.44 ± 0.23d	4.88 ± 0.96d	1.46 ± 0.32d	2.12 ± 0.63d
AICAR	1.28 ± 0.31d	4.54 ± 0.55d	1.82 ± 0.22d	2.34 ± 0.40d
Metformin	1.26 ± 0.37d	4.72 ± 0.56d	1.60 ± 0.27d	2.52 ± 0.59d

^bP < 0.01 vs the normal control group,

^dP < 0.01 vs the model group (by ANOVA). TC: Total cholesterol; TG: Triglycerides; LDL-C: Low-density lipoprotein cholesterol; HDL-C: High-density lipoprotein cholesterol.