TLR2 and TLR4 polymorphisms influence mRNA and protein expression in colorectal cancer

Table 3 Allele and genotype frequencies of TLR2 and TLR4 polymorphisms and multiple logistic regression analysis between case and control groups n (%)

Polymorphisms	Statistical Models	Genotypes /alleles	C	CRC	P value
TLR2-196 to -174del			n = 240	n = 188
		ins/ins	200 (83.0)	144 (77.0)
		ins/del	36 (15.0)	39 (21.0)
		del/del	4 (2.0)	5 (3.0)
		ins	436 (0.9)	327 (0.9)
		del	44 (0.1)	49 (0.1)
	Dominant	ins/ins	200 (83.3)	144 (76.9)	0.038
		ins/del + del/del	40 (16.7)	44 (23.1)
	OR (95%CI)		1.72(1.03-2.89)
	Recessive	ins/ins + ins/del	236 (98.3)	183 (97.3)	0.360
		del/del	4 (1.7)	5 (2.7)
	OR (95%CI)		1.90 (0.48-7.58)
	Log-additive	ins/ins	200 (83.0)	144 (77.0)	0.039
		ins/del	36 (15.0)	39 (21.0)
		del/del	4 (2.0)	5 (3.0)
	OR (95%CI)		1.59 (1.02-2.48)
TLR4 -1607T/C			n = 208	n = 190
		T/T	166 (79.0)	154 (81.0)
		T/C	39 (19.0)	33 (17.0)
		C/C	3 (2.0)	3 (2.0)
		T	371 (0.9)	341 (0.9)
		C	45 (0.1)	39 (0.1)
	Dominant	T/T	166 (79.0)	154 (81.0)	0.860
		T/C + C/C	42 (21.0)	36 (19.0)
	OR (95%CI)		0.95 (0.56-1.63)
	Recessive	T/T + T/C	205 (98.0)	187 (98.0)	0.940
		C/C	3 (2.0)	3 (2.0)
	OR (95%CI)		0.93 (0.14-5.95)
	Log-additive	T/T	166 (79.0)	154 (81.0)	0.860
		T/C	39 (19.0)	33 (17.0)
		C/C	3 (2.0)	3 (2.0)
	OR (95%CI)		0.96 (0.59-1.55)
TLR4 +896A/G			n = 240	n = 190
	Dominant	A/A	224 (93.3)	172 (90.5)	0.520
		A/G	16 (6.7)	18 (9.5)
	OR (95%CI)		1.28 (0.60-2.73)
		A	464 (0.97)	349 (0.95)
		G	16 (0.03)	17 (0.05)

The data are adjusted for age, gender, smoking and drinking status. CRC: Colorectal cancer; C: Controls; OR: Odds ratio.