High level of intercellular adhesion molecule-1 affects prognosis of patients with hepatocellular carcinoma

Table 2 Correlation between the clinicopathological variables and serum intercellular adhesion molecule-1 level in hepatocellular carcinoma n (%)

Clinical character	Variable	Number of patients	ICAM-1 level		χ2	P value
			Low1	High2
Age (yr)	≤ 55	161	37 (23.0)	124 (77.0)	0.265	0.607
	> 55	75	15 (20.0)	60 (80.0)
Gender	Male	207	44 (21.3)	163 (78.7)	0.593	0.441
	Female	29	8 (27.6)	21 (72.4)
Family history	No	203	42 (20.7)	161 (79.3)	1.527	0.217
	Yes	33	10 (30.3)	23 (69.7)
HBsAg	Negative	34	7 (20.6)	27 (79.4)	0.048	0.826
	Positive	202	45 (22.3)	157 (77.7)
AFP (ng/mL)	≤ 100	99	29 (29.3)	70 (70.7)	5.231	0.022
	> 100	137	23 (16.8)	114 (83.2)
Median size (cm)	≤ 5	32	9 (28.1)	23 (71.9)	0.800	0.371
	> 5	204	43 (21.1)	161 (78.9)
Cirrhosis	No	25	2 (8.0)	23 (92.0)	3.206	0.073
	Yes	211	50 (23.7)	161 (76.3)
Tumor number	Single	149	37 (24.8)	112 (75.2)	1.842	0.175
	Multiple	87	15 (17.2)	72 (82.8)
NLR	≤ 2.31	130	31 (23.8)	99 (76.2)	0.553	0.457
	> 2.31	106	21 (19.8)	85 (80.2)
TNM stage	I-II	108	37 (34.3)	71 (65.7)	17.324	< 0.001
	III-IV	128	15 (11.7)	113 (88.3)
PVTT	No	184	48 (26.1)	136 (73.9)	7.985	0.005
	Yes	52	4 (7.7)	48 (92.3)
Distant metastasis	No	217	52 (24.0)	165 (76.0)	5.840	0.016
	Yes	19	0 (0)	19 (100)
Recurrence	No	139	24 (17.3)	115 (82.7)	4.475	0.034
	Yes	97	28 (28.9)	69 (71.1)

¹Low, ICAM-1 ≤ 684 ng/mL;

²High, ICAM-1 > 684 ng/mL. HBsAg: Hepatitis B surface antigen; ICAM-1: Intercellular adhesion molecule-1; AFP: Alpha-fetoprotein; NLR: Neutrophil-to-lymphocyte ratio; TNM: Tumor-node-metastasis; PVTT: Portal vein tumor thrombus.