Loss of Dicer1 impairs hepatocyte survival and leads to chronic inflammation and progenitor cell activation

Figure 2 Morphology and metabolism changes of Dicer1^-/- liver at indicated age. A, B: Body weight and the ratio of liver weight/body weight (l.w./b.w.) in wild-type and Dicer1^-/- mice (mean ± SD; n = 6), ^aP < 0.05 vs wild-type mice, l.w. vs b.w.; C: Gross observation of the livers (Scale bar: 1 cm). PAS staining and Oil Red O staining were performed respectively to detect the abnormal changes of Dicer1-deficient livers (Scale bar: 100 μm).