Histological mixed-type as an independent prognostic factor in stage I gastric carcinoma

Table 1 Association between clinicopathological characteristics and histological mixed-type in pathological stage I gastric cancer n (%)

	n	Histological type		P value
		Mixed-type	Non-mixed-type
Sex	446	113	333
Male	305	76 (67)	229 (69)
Female	141	37 (33)	104 (31)	0.7651
Age (yr)
< 65	233	52 (46)	181 (54)
≥ 65	213	61 (54)	152 (46)	0.1252
Location
Upper	340	81 (72)	259 (78)
Middle or Lower	106	32 (28)	74 (22)	0.1883
Histological type (JCGC)
Differentiated	251	60 (53)	191 (57)
Undifferentiated	195	53 (47)	142 (43)	0.4302
Macroscopic appearance (JCGC)
Type 0	402	99 (88)	303 (91)
Type 1-5	44	14 (12)	30 (9)	0.2977
Tumor size (mm)
< 25	214	36 (32)	178 (53)
≥ 25	232	77 (68)	155 (47)	< 0.00011
Venous invasion
0	410	102 (90)	308 (92)
1-3	36	11 (10)	25 (8)	0.4526
Lymphatic invasion
0	370	82 (73)	288 (86)
1-3	76	31 (27)	45 (14)	0.00111
TNM classification
pT categories
T1a	11	34 (30)	185 (56)
T1b	11	59 (52)	124 (37)
T2	31	20 (18)	24 (7)	< 0.00011
pN categories
N0	427	105 (93)	322 (97)
N1	19	8 (7)	11 (3)	0.1476

¹Statistically significant values (P < 0.05). P values were calculated by χ² or Fisher’s exact test. JCGC: Japanese classification of gastric carcinoma.