Thrombomodulin in the management of acute cholangitis-induced disseminated intravascular coagulation

doi:10.3748/wjg.v21.i2.533

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Jan 14, 2015 (publication date) through May 8, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jan 14, 2015; 21(2): 533-540
Published online Jan 14, 2015. doi: 10.3748/wjg.v21.i2.533

Table 2 Comparison of patient characteristics between the recombinant human soluble thrombomodulin and control groups

	rTM group(n = 30)	Control group (n = 36)	P value
Age (yr)	77.0 ± 7.7	75.7 ± 9.4	0.554
Sex (Male/Female)	22/8	21/15	0.203
Primary disease (Benign/Malignant)	21/9	21/15	0.327
Severity of cholangitis (Severe/Moderate)	28/2	32/4	0.845
DIC score	5.4 ± 1.4	5.2 ± 1.2	0.523
SIRS score	2.4 ± 1.3	2.6 ± 1.0	0.599
Biliary drainage	25	24	0.123
Anticoagulant drug
AT	26	16	< 0.001
GM	14	30	0.002
NM	4	18	0.004
DS	0	6	0.019
Antibiotics
MEPM	19	14	0.048
IPM/CS	0	7	0.031
DRPM	5	0	0.037
SBT/CPZ	5	14	0.047
TAZ/PIPC	1	1	0.556

DIC: Disseminated intravascular coagulation; SIRS: Systemic inflammatory response syndrome; rTM: Recombinant human soluble thrombomodulin; AT: Antithrombin; GM: Gabexate mesilate; NM: Nafamostat mesilate; DS: Danaparoid sodium; MEPN: Meropenem; IPM/CS: Imipenem/Cilastatin; DRPM: Doripenem; SBT/CPZ: Sulbactam/Cefoperazone; TAZ/PIPC: Tazobactam/Piperacilin.

Citation: Suetani K, Okuse C, Nakahara K, Michikawa Y, Noguchi Y, Suzuki M, Morita R, Sato N, Kato M, Itoh F. Thrombomodulin in the management of acute cholangitis-induced disseminated intravascular coagulation. World J Gastroenterol 2015; 21(2): 533-540
URL: https://www.wjgnet.com/1007-9327/full/v21/i2/533.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i2.533