Basic Study
Copyright ©The Author(s) 2015.
World J Gastroenterol. Jan 14, 2015; 21(2): 465-474
Published online Jan 14, 2015. doi: 10.3748/wjg.v21.i2.465
Table 1 Histologic scores
Grade 0Normal tissue
Grade 1One or a few multifocal mononuclear cell infiltrates in the lamina propria
Minimal epithelial hyperplasia
Slight to no depletion of mucus from goblet cells
Grade 2Lesions tended to involve more of the intestine than grade 1 lesions
Several multifocal, mild inflammatory cell infiltrates in the lamina propria
Mild epithelial hyperplasia and mucin depletion
Small epithelial erosions
Grade 3Lesions involved a large area of the mucosa or were more frequent than grade 2 lesions
Moderate inflammation with the involvement of submucosa
Mixture of mononuclear cells as well as neutrophils, and crypt abscesses
Moderate epithelial hyperplasia and mucin depletion
Ulcers were occasionally observed
Grade 4Lesions usually involved most of the intestinal section and were more severe than grade 3 lesions
Severe inflammation including mononuclear cells and neutrophils with transmural involvement
Marked epithelial hyperplasia
Crypt abscesses and ulcers