Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction

Figure 5 Calcitonin-gene-related peptide level in serum and colonic tissues. A: CGRP level in serum measured by ELISA; B: CGRP expression in colonic tissues measured by immunochemistry. Data are presented as mean ± SD, ^bP < 0.01 vs control; ^cP < 0.05, ^dP < 0.01 vs IBS. Statistical comparisons were performed using One-way ANOVA followed by Dunnett’s test using GraphPad Prism 5.0. (n = 3 or 4). CGRP: Calcitonin-gene-related peptide; IBS: Irritable bowel syndrome; SGD: Shugan decoction; TXYF: TongXieYaoFang.