Efficacy of moxifloxacin-based sequential therapy for first-line eradication of Helicobacter pylori infection in gastrointestinal disease

Table 1 Demographic and clinical data at baseline (intention-to-treat population) n (%)

	MOX-ST	CLA-ST	P value
Included in ITT analysis	80	81	NS
Age (yr), mean ± SD	59.3 ± 13.1	59.4 ± 13.1	0.235
Gender (male)	34 (42.5)	33 (40.7)	0.773
BMI (kg/m2), mean ± SD	22.9 ± 2.2	22.7 ± 2.9	0.352
Current smoker	11 (13.7)	10 (12.3)	0.385
Alcohol drinking	13 (16.2)	9 (11.1)	0.351
Diabetes	5 (6.2)	8 (9.8)	0.125
Hypertension	19 (23.7)	23 (28.3)	0.407
Previous history of peptic ulcer	12 (15.0)	9 (11.1)	0.348
Endoscopic diagnosis			0.624
Gastritis	70 (87.6)	70 (86.6)
Gastric ulcer	4 (5.0)	5 (6.1)
Duodenal ulcer	1 (1.2)	1 (1.2)
Gastric and duodenal ulcer	1 (1.2)	0 (0.0)
Adenoma	4 (5.0)	4 (4.9)
Dysplasia	0 (0.0)	1 (1.2)
Positive CLOtest	59 (73.7)	62 (76.5)	0.955
H. pylori colonization			0.588
Negative	3 (3.7)	5 (6.1)
Mild	34 (42.5)	36 (44.4)
Moderate	32 (40.0)	24 (29.6)
Marked	11 (13.8)	16 (19.9)
Atrophic change	8 (10.0)	2 (2.4)	0.087
Intestinal metaplasia	10 (12.5)	13 (16.0)	0.761
Drop out	2 (2.5)	4 (4.9)	0.113
Noncompliance	0 (0.0)	0 (0.0)
Follow-up loss	2 (2.5)	4 (4.9)
Discontinued therapy due to adverse events	0 (0.0)	0 (0.0)

MOX-ST: 14-d moxifloxacin-based sequential therapy; CLA-ST: 14-d clarithromycin-based sequential therapy; ITT: Intention-to-treat; SD: Standard deviation; BMI: Body mass index; CLOtest: Rapid urease test; H. pylori: Helicobacter pylori; NS: Not significant; BMI: Body mass index.