Pathophysiology of functional heartburn based on Rome III criteria in Japanese patients

Table 2 Questionnaire scores

Questionnaire	pH-POS	HE	FH	P value1
	(n = 22)	(n = 34)	(n = 22)
FSSG score (median)	16.4 ± 7.2	18.4 ± 9.6	19.5 ± 10.3	0.6
QUEST score (median)	5.8 ± 4.7	5.1 ± 4.5	4.2 ± 4.2	0.5
GSRS scale
Over all	2.5 ± 0.6	2.5 ± 0.8	2.2 ± 1.0	0.5
Acid reflux	3.4 ± 1.6	3.2 ± 1.5	3.0 ± 1.4	0.7
Abdominal pain	2.5 ± 1.1	2.4 ± 1.3	2.3 ± 1.3	0.7
Indigestion	2.9 ± 1.8	2.8 ± 1.1	2.5 ± 1.4	0.5
Diarrhea	1.6 ± 0.7	1.9 ± 1.2	1.7 ± 0.1	0.8
Constipation	2.3 ± 1.4	2.4 ± 1.2	2.0 ± 1.1	0.3
SF-36 scale
Physical Functioning	46.5 ± 11.1	45.1 ± 16.2	44.7 ± 16.1	0.9
Role Physical	40.5 ± 13.2	41.0 ± 15.4	40.4 ± 15.1	0.9
Bodily Pain	43.6 ± 9.1	44.1 ± 10.1	43.5 ± 11.8	0.9
General Health	38.9 ± 9.8	42.1 ± 6.3	43.1 ± 10.5	0.5
Vitality	46.0 ± 10.6	45.5 ± 9.5	45.4 ± 11.1	0.9
Social Functioning	44.8 ± 10.6	39.2 ± 13.1	44.6 ± 11.2	0.2
Role Emotional	41.9 ± 14.3	42.5 ± 14.3	44.6 ± 14.2	0.8
Mental Health	43.9 ± 10.5	42.2 ± 11.0	41.8 ± 13.8	0.9

¹Determined by the Kruskal-Wallis test; Data are expressed as mean ± SD unless otherwise indicated. FH: Functional heartburn; FSSG: Frequency scale for the symptoms of gastroesophageal reflux disease; GSRS: Gastrointestinal symptoms rating scale; HE: Hypersensitive esophagus (non-excessive esophageal acid exposure time and positive symptom index); pH-POS: Excessive intraesophageal acid exposure time; QUEST: Questionnaire for the diagnosis of reflux disease.