Meta-Analysis
Copyright ©The Author(s) 2015.
World J Gastroenterol. Apr 7, 2015; 21(13): 4038-4047
Published online Apr 7, 2015. doi: 10.3748/wjg.v21.i13.4038
Table 1 Clinical data of included studies
Ref.Population characteristicsLC in ALDBone fractures
Osteoporosis
ALD BMDControl BMD
Fracture siteALD fractureTotal ALDControl fractureTotal controlALD osteoporosisTotal ALDControl osteoporosisTotal control
Lindsell et al[44]149 CLD (72 ALD, 77 non-alcoholic CLD), 149 normal controls0Rib or clavicle187210149 (normal control)
Diamond et al[46]115 CLD (M: 72, F: 43), 113 Controls (M: 52, F: 61)UnidentifiablePeripheral bone12401275 (other CLD)
Bonkovsky et al[23]133 CLD (M: 70, F: 63, Mean age: 47 ± 1.1)Unidentifiable5 (L), 4 (FN)3215 (L), 5 (FN)48 (other LC)
Ninkovic et al[39]37 CLD (6 ALD, 31 other CLD) (M: 20, F: 17, Mean age: 51.3, range: 32-65)UnidentifiableVertebra661731 (other CLD)
Ninkovic et al[21]243 CLD (M: 128, F: 115, Mean age: 51.1 ± 10.9)Predominantly LC4655 (HCV)T (L1-4): -0.94 ± 1.38, T (FN): -1.49 ± 1.15T (L1-4): -1.59 ± 1.6, T (FN): -1.66 ± 1.27
Carey et al[45]207 CLD (66 ALD, 73 HCV + ALD, 68 HCV) (M: 131, F: 76, Mean age: 51, range: 32-68)UnidentifiableOverall fractures21661368 (HCV)12661968 (HCV)T (L1-4): -0.87 ± 1.61T (L1-4): -1.43 ± 1.68
Kim et al[47]18 ALD (Mean age: 50.2 ± 9.5), 18 normal controls (Mean age: 51.2 ± 14)0418318 (normal control)T (L2-4): 1.04 ± 0.14, T (FN): 0.844 ± 0.12T (L2-4): 1.131 ± 0.22, T (FN): 0.908 ± 0.15
Sokhi et al[22]104 CLD (M: 54, F: 50, Mean age: 54.4 ± 12.9)All (17)1769 (LC-HCV)T (L2-4): -1.17 ± 0.16, T (FN): 0.97 ± 0.18T (L2-4): 1.23 ± 0.25, T (FN): 0.98 ± 0.16
Alvisa-Negrín et al[43]77 ALD (M: 68, F: 9, Mean age: 50.43 ± 10.81), 28 normal controls (M: 25, F: 3, Mean age: 49.83 ± 9.24)41 ALC, 30 Non-LC977028 (normal control)1T (L): -1.2 ± 1.16, T (FN): -1.1 ± 1.281T (L): -0.49 ± 0.89, T (FN): -0.5 ± 1.23
González-Reimers et al[40]124 ALD (Mean age: 50.5 ± 11.23), 38 Controls (Mean age: 48.47 ± 11.08)51 ALC, 61 Non-LC12438 (normal control)2T (LS): -1.17 ± 1.22, T (FN): -1.24 ± 1.382T (LS): -0.5 ± 0.86, T (FN): -0.36 ± 1.34
Mitchell et al[24]117 CLD (M: 74, F: 43, Mean age: 50.4 ± 10.5)Unidentifiable2046 (viral CLD)T (L1-4): -1.51 ± 1.35, T (FN): -1.31 ± 1.02T (L1-4): -1.08 ± 1.35, T (FN): -1.11 ± 1.07
Mahmoudi et al[25]109 CLD (M: 72, mean age: 55.3 ± 11.4, F: 37, mean age: 65.2 ± 11)All (31)3143 (LC-HCV)T (L1-4): -0.34 ± 1.46, T (FN): -0.07 ± 1.45T (L1-4): -0.83 ± 1.66, T (FN): -0.56 ± 1.49
Wibaux et al[42]99 CLD (M: 79, F: 20, mean age: 55 ± 8)All (39)Vertebra17391960 (other CLD)
Choudhary et al[26]115 LC (M: 107, F: 8, mean age: 49 ± 5.5)All (67)16671048 (viral LC)
González-Reimers et al[41]90 ALD (Mean age: 50.14 ± 10.49), 30 normal controls (Mean age: 50.11 ± 10.4)40 ALC, 48 Non-LCOverall fractures4990030 (normal control)3T (L): -1.15 ± 1.183T (L): -0.56 ± 0.9