Diagnostic value of PIVKA-II and alpha-fetoprotein in hepatitis B virus-associated hepatocellular carcinoma

Table 2 Comparision of baseline characteristics according to cutoff values of prothrombin induced by vitamin K absence-II (40 mAU/mL) and AFP (10 ng/mL)

	PIVKA-II < 40 AFP < 10	PIVKA-II≥40 AFP < 10	PIVKA-II < 40 AFP < 10	PIVKA-II≥40 AFP≥10	P value
Number	918	125	108	104
Age (yr)	47.9 (17-97)	48.4 (18-83)	51.4 (23-92)	55 (25-88)	0.0001
Gender (M:F)	578:340	97:28	67:41	82:22	0.0001
INR	1.0 (0.8-3.2)	1.0 (0.8-2.3)	1.1 (0.9-2.1)	1.13 (0.7-8.9)	0.0001
Albumin (g/dL)	4.5 (0.5-5.3)	2.9 (0.6-9.6)	3.8 (2-5.2)	3.5 (1.7-4.9)	0.0001
TB (mg/dL)	0.7 (0.2-18.9)	0.7 (0.2-19.2)	1.1 (0.2-17.3)	1.1 (0.3-14.7)	0.0001
ALT (IU/L)	25.4 (2-803)	30.1 (5-1664)	50 (9-1531)	43.4 (9-3112)	0.0001
MELD score	7.4	8.2	9.9	10.5	0.0001
LC, n (%)	188 (20.5)	42 (33.6)	50 (46.3)	89 (85.6)	0.0001
HCC, n (%)	21 (2.3)	30 (24)	20 (18.5)	86 (82.7)	0.0001

Data are expressed as number or median (range). PIVKA-II: Prothrombin induced by vitamin K absence-II; AFP: Alpha-fetoprotein; M: Male; F: Female; INR: International normalized ratio; TB: Total bilirubin; ALT: Alanine aminotransferase; MELD: Model for end-stage liver disease; LC: Liver cirrhosis; HCC: Hepatocellular carcinoma.