Effect of entacapone on colon motility and ion transport in a rat model of Parkinson’s disease

Figure 2 Effect of entacapone on colon smooth muscle motility in 6-OHDA Parkinson’s disease rats. A: Inhibitory effect of entacapone on colon longitudinal muscle contraction; B: Dose-response curve effect of entacapone on colon smooth muscle motility in 6-OHDA rats (n = 30); C: Representative tracing of strips when using entacapone (ENT) and β₂ receptor antagonist ICI-118,551 (1.0 × 10^-5 mol/L) in 6-OHDA rats; D: The role of β₂ receptor in entacapone-induced effect of smooth muscle inhibition (n = 9, ^aP < 0.05 vs control).