Hepatitis C virus-specific cytotoxic T cell response restoration after treatment-induced hepatitis C virus control

Figure 3 Representative FACS^® dot-plots of peripheral blood mononuclear cells from a sustained viral responder (A) and a null responder (B) after treatment with pegylated-α2-interferon plus ribavirin. The dot-plots show the frequency of hepatitis C virus (HCV)-specific cytotoxic T lymphocyte (CTLs) directly ex-vivo and after specific in-vitro challenge, besides the PD-1 phenotype pre- and after treatment. PBL: Peripheral blood lymphocytes; MFI: Mean fluorescence intensity; tx: Treatment; NA: Not available; PentNS3₁₄₀₆: Multimeric complexes HLA-A2/NS3₁₄₀₆ phycoerithryn labelled; PentNS3₁₀₇₃: Multimeric complexes HLA-A2/NS3₁₀₇₃ phycoerithryn labelled.