Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from different geographical locations

Table 3 Characteristics of the patients according to telomerase reverse transcriptase promoter mutation status n (%)

Variable	Overall series	TERT promoter mutated	TERT promoter non-mutated	P value
	(n = 44)	(n = 15)	(n = 29)
Gender
Male	27	10	17	0.2059
Female	1	1	0
Age
≥ 60 yr	9	3 (33)	6 (67)	0.6547
< 60 yr	19	8 (42)	11 (58)
Geographical origin
African	15	8 (53)	7 (47)	0.0528
Non-African	29	7 (24)	22 (76)
HBV DNA
Positive	23	6 (26)	17 (74)	0.2950
Negative	18	7 (39)	11 (61)
TP53
Mutated	6	3 (50)	3 (50)	0.6315
Wild-type	38	11 (29)	27 (71)
MDM2 SNP 309
TT	18	8 (44)	10 (56)
TG	15	2 (13)	13 (87)	0.0528 (vs TT)
GG	11	4 (36)	7 (64)

TERT: Telomerase reverse transcriptase; SNP: Single nucleotide polymorphism; MDM2: Murine double minute 2; HBV: Hepatitis B viral.