Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from different geographical locations

Table 2 Telomerase reverse transcriptase promoter mutation analysis of hepatocellular carcinoma tumors

Country	TERT mutations		p53 mutations		MDM2	HBV	Stage
	C228T	C250T	Codon	Amino Acid change	SNP 309
Japan	C228T	WT	6 bp del	Del (AGCTAC)	G/G	Minus1	Unknown
Japan	C228T	WT		WT	T/G	Minus1	Unknown
Japan	C228T	WT		WT	T/G	Minus1	Unknown
Japan	WT	C250T		WT	G/G	Minus1	Unknown
Japan	WT	WT		WT	T/G	Minus1	Unknown
Japan	WT	WT		WT	T/G	Minus1	Unknown
Japan	WT	WT		WT	T/G	Minus1	Unknown
Japan	WT	WT		WT	T/G	Minus1	Unknown
Japan	WT	WT		WT	T/G	plus1	Unknown
Japan	WT	WT		WT	G/G	Minus1	Unknown
Japan	WT	WT		WT	T/G	Minus1	Unknown
China	WT	WT	281	C > A Asp > Glu	T/T	plus1	Unknown
China	WT	WT		WT	G/G	Plus1	Unknown
China	WT	WT		WT	T/G	Plus1	Unknown
China	WT	WT		WT	T/T	Plus1	Unknown
China	WT	WT		WT	G/G	Plus1	Unknown
China	WT	WT		WT	T/T	Plus1	Unknown
China	WT	WT		WT	G/G	Plus2	Unknown
China	WT	WT		WT	G/G	plus1	Unknown
Israel	WT	WT		WT	T/G	Minus1	Unknown
Mozambique	C228T	WT	157	G > T Val > Phe	T/T	Plus1	Late
Mozambique	C228T	WT		WT	T/T	Plus2	Late
Mozambique	WT	C250T		WT	T/T	Plus2	Late
Mozambique	WT	C250T	249	G > T Arg > Ser	T/T	Minus1	Early
Mozambique	WT	WT		WT	T/T	Plus2	Late
Mozambique	WT	WT	249	G > T Arg > Ser	T/T	Plus1	Late
Transkei	C228T	WT		WT	T/T	NT	Late
Transkei	C228T	WT		WT	T/T	NT	Late
Transkei	WT	WT		WT	T/T	NT	Early
Transkei	WT	WT		WT	T/T	Plus1	Late
Lesotho	WT	C250T		WT	T/T	Plus2	Early
Lesotho	WT	WT		WT	T/G	Plus2	late
Swaziland	WT	WT		WT	T/T	Plus	Early
South Africa	C228T	WT		WT	T/T	Plus2	Late
South Africa	WT	WT		WT	T/G	Plus2	Late
Germany	C228T	WT		WT	G/G	Minus1	Metastasis
Germany	C228T	WT	273	C > T Arg > Cys	T/T	Minus1	HCC
Germany	WT	C250T		WT	G/G	Plus2	HCC
Germany	WT	WT		WT	G/G	Minus1	Unknown
Germany	WT	WT		WT	G/G	Minus1	Metastasis
Germany	WT	WT		WT	T/T	Plus2	Unknown
Germany	WT	WT		WT	T/G	Plus2	HCC
France	WT	WT		WT	T/G	Minus1	Unknown
France	WT	WT		WT	T/G	Minus1	Unknown

¹means reference 17;

²means reference 18. The collection of tumor samples used for telomerase reverse transcriptase (TERT) promoter mutation analysis is displayed together with complementary data. WT: Wild type; Del: Deletion; HCC: Hepatocellular carcinoma; SNP: Single nucleotide polymorphism; MDM2: Murine double minute 2; HBV: Hepatitis B viral.