Review
Copyright ©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Mar 7, 2014; 20(9): 2127-2135
Published online Mar 7, 2014. doi: 10.3748/wjg.v20.i9.2127
Table 1 Gender differences in primary biliary cirrhosis and autoimmune hepatitis
Primary biliary cirrhosisAutoimmune hepatitis
M/F ratio 1:10M/F ratio 1:3.6
Age at diagnosis higher in M than in F (62 yr vs 51 yr)Normalization of ALT levels after 6 mo of corticosteroid treatment less frequent in M than in F
M less symptomatic than F: pruritus, abdominal pain/discomfort and constitutional symptoms more common in F; jaundice and upper gastrointestinal bleeding more common in MBetter long-term survival and outcome in M than F
Concomitant autoimmune diseases more common in F (sicca syndrome, sclerodermia, raynaud phenomenon), whereas HCC complication are significantly greater in MDecrease of severity during second trimester of pregnancy and possible onset of acute exacerbation after delivery
ALP, ALT and gGT higher in M than FHaplotype HLA A1-B8-DR3 more prevalent in M than in F
Piecemealnecrosis and pseudoxanthomatousHigher frequency of concurrent immunological
trasformation greater in symptomatic Fdisorders at presentation in F than M