Management of locally advanced and metastatic colon cancer in elderly patients

Table 1 Chemotherapy regimen in locally advanced and metastatic colon cancer

No.	Regimen	Dosing	Frequency	Adjuvant	Palliative
1	5-FU/LV	Leucovorin 400 mg/m2 IV over 2 h before 5-FU on day 1	Every 2 wk	Y	Y
		5-FU 400 mg/m2 IV bolus on day 1, followed by 2400 mg/m2 IV over 46 h
2	Capecitabine	Capecitabine 1000-1250 mg/m2 by mouth twice daily for 2 wk, then 1 wk off	Every 3 wk	Y	Y
3	FOLFOX	Leucovorin 400 mg/m2 IV over 2 h before 5-FU on day 1	Every 2 wk	Y	Y
		5-FU 400 mg/m2 IV bolus on day 1, followed by 2400 mg/m2 IV over 46 h
		Oxaliplatin 85 mg/m2 IV on day 1
4	CAPOX	Capecitabine 850-1000 mg/m2 by mouth twice daily for 2 wk, then 1 wk off	Every 3 wk	Y	Y
		Oxaliplatin 130 mg/m2 IV on day 1
5	FOLFIRI	Leucovorin 400 mg/m2 IV over 2 h before 5-FU on day 1	Every 2 wk	N	Y
		5-FU 400 mg/m2 IV bolus on day 1, followed by 2400 mg/m2 IV over 46 h
		Irinotecan 180 mg/m2 IV over 90 min on day 1
6	FOLFOX + Bevacizumab	Leucovorin 400 mg/m2 IV over 2 h before 5-FU on day 1	Every 2 wk	N	Y
		5-FU 400 mg/m2 IV bolus on day 1, followed by 2400 mg/m2 IV over 46 h
		Oxaliplatin 85 mg/m2 IV on day 1
		Bevacizumab 5 mg/kg IV on day 1
7	FOLFIRI + Bevacizumab	Leucovorin 400 mg/m2 IV over 2 h before 5-FU on day 1	Every 2 wk	N	Y
		5-FU 400 mg/m2 IV bolus on day 1, followed by 2400 mg/m2 IV over 46 h
		Irinotecan 180 mg/m2 IV over 90 min on day 1
		Bevacizumab 5 mg/kg IV on day 1
8	CAPOX + Bevacizumab	Capecitabine 850-1000 mg/m2 by mouth twice daily for 2 wk, then 1 wk off	Every 3 wk	N	Y
		Oxaliplatin 130 mg/m2 IV on day 1
		Bevacizumab 7.5 mg/kg IV on day 1
9	Capecitabine + Bevacizumab	Capecitabine 850-1000 mg/m2 by mouth twice daily for 2 wk, then 1 wk off	Every 3 wk	N	Y
		Bevacizumab 7.5 mg/kg IV on day 1
10	5-FU/LV + Bevacizumab	Leucovorin 400 mg/m2 IV over 2 h before 5-FU on day 1	Every 2 wk	N	Y
		5-FU 400 mg/m2 IV bolus on day 1, followed by 2400 mg/m2 IV over 46 h
		Bevacizumab 5 mg/kg IV on day 1
11	FOLFIRI + Cetuximab	Leucovorin 400 mg/m2 IV over 2 h before 5-FU on day 1	Every 2 wk	N	Y
		5-FU 400 mg/m2 IV bolus on day 1, followed by 2400 mg/m2 IV over 46 h
		Irinotecan 180 mg/m2 IV over 90 min on day 1
		Cetuximab 400 mg/m2 IV loading on treatment day 1, then 250 mg/m2 IV every week
12	FOLFIRI + Ablifercept	Leucovorin 400 mg/m2 IV over 2 h before 5-FU on day 1	Every 2 wk	N	Y
		5-FU 400 mg/m2 IV bolus on day 1, followed by 2400 mg/m2 IV over 46 h
		Irinotecan 180 mg/m2 IV over 90 min on day 1
		Aflibercept 4 mg/kg, over 1 h on day 1
13	Panitumumab	Panitumumab 6 mg/kg IV	Every 2 wk	N	Y
14	Regorafenib	Regorafenib 160 mg by mouth once daily for 3 wk, then 1 wk off	Every 4 wk	N	Y

5-FU: Fluorouracil.