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Copyright ©2014 Baishideng Publishing Group Co.
World J Gastroenterol. Feb 7, 2014; 20(5): 1228-1237
Published online Feb 7, 2014. doi: 10.3748/wjg.v20.i5.1228
Table 1 Clinical studies of neurologic disorders in inflammatory bowel disease
AuthorYearCountryStudy designTotal patientsType of IBDPatients with NCAge (range, yr)SexOther EIMAssociated with IBD exacerbationIncidence of NC
Lossos et al[21]1995IsraelRetrospective, computerized search638377 CD261 UC10 CD patients9 UC patients11-7111 M8 F50%2 patients (10%)19 patients (3%)
Elsehety et al[15]1997United StatesRetrospective253CDProbable: 49 patients Possible: 35 patients Total: 84 patientsNRNRNR5 patients (6%)Probable: 19.3% Possible: 13.9%Total: 33.2%
Oliveira et al[14]2008BrazilProspectively, clinic-based, PN especially studied8231 CD51 UC16 CD patients23 UC patients43 CD151 UC15 M24 FNRNRPN:51.6% CD45.1% UC Headache:54.8% CD57% UC
Sassi et al[23]2009TunisProspective, prevalence study PN10288 CD14 UC6 UC patients23 CD patients22-647 F2 M33%29%8.80%
Benavente et al[12]2011SpainRetrospective, hospitalized patients84NR13 UC patients12 CD patients17-7412 M13 F4%10 patients (40%)30%
Shen et al[20]2012United StatesQuestionnaire-based, study of PN symptoms only173102 CD71 UC67 patientsNRNRNRNR38.70%
Figueroa et al[18]2013United StatesRetrospective, observational population based-cohort772342 CD430 UC9 patients/12 events6 UC patients3 CD patients21-835 F4 MNR8 patients72 patients/100000 person-years
Babali et al[17]2013GreeceProspective study of subclinical PN in asymptomatic patients45330 CD15 UC0 patientsNRNRNRNRNo patients had subclinical neuropathy