MicroRNAs in colorectal cancer: Role in metastasis and clinical perspectives

Table 2 MicroRNAs and invasion

MicroRNAs	Dysregulation	Remarks	Ref.
miR-31	↑	Contributed to the invasive nature of CRC cells in vitro and in vivo	[76]
miR-122	↑	Non-neoplastic tissue to dysplasia	[77]
	↓	Dysplasia to inflammatory bowel disease-associated CRC	[77]
miR-200 family	↑	Associated with acquiring an aggressive phenotype	[78]
miR-328	↓	Accompanied by a high fraction of side population (SP) cells showing cancer stem like properties	[79]
miR-143	↓	Stimulated cell growth, migration and invasion	[80]
miR-145, miR-103 and miR-107	↑	Promoted local invasion and liver metastasis in a mouse model	[81]
miR-29a	↑	Elevated in CRC tumor samples compared to normal epithelial tissue; a specific and sensitive marker discriminating CRC with liver metastases from non-metastatic CRC	[82,83]
miR-21, miR-17, miR-19a	↑	Favored cell proliferation and CRC metastasis	[84]

CRC: Colorectal cancer; miRNA: MicroRNA.