Azathioprine does not reduce adenoma formation in a mouse model of sporadic intestinal tumorigenesis

Figure 1 Treatment with azathioprine results in severe drug associated toxicity. A: Weight curve of female mice. All azathioprine treated female mice had to be sacrificed three to four weeks after start of the treatment due to progressive weight loss; B: Survival curve of female mice; C: Weight curve of male mice. After 9 to 10 wk of treatment male mice started to show signs of toxicity. Veh: Vehicle; Aza: Azathioprine.