Insulin-like growth factor receptor-1 overexpression is associated with poor response of rectal cancers to radiotherapy

doi:10.3748/wjg.v20.i43.16268

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 21, 2014; 20(43): 16268-16274
Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.16268

Table 2 Relationship between insulin-like growth factor receptor-1 expression on pre-radiation biopsy specimens and tumor radiosensitivity in rectal carcinoma

IGF-1R expression	Cases	RCRG			P value	r
IGF-1R expression	Cases	1	2	3	P value	r
IHC
0-+	33	18	9	6
++-+++	54	13	19	22	< 0.001	0.401
RT-PCR
-	10	8	2	0
+	77	23	26	28	< 0.001	0.497

RCRG: Rectal Cancer Regression Grades; IHC: Immunohistochemistry; RT-PCR: Reverse transcription-polymerase chain reaction; IGF-1R: Insulin-like growth factor receptor-1.

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Citation: Wu XY, Wu ZF, Cao QH, Chen C, Chen ZW, Xu Z, Li WS, Liu FK, Yao XQ, Li G. Insulin-like growth factor receptor-1 overexpression is associated with poor response of rectal cancers to radiotherapy. World J Gastroenterol 2014; 20(43): 16268-16274
URL: https://www.wjgnet.com/1007-9327/full/v20/i43/16268.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i43.16268

Wu XY, Wu ZF, Cao QH, Chen C, Chen ZW, Xu Z, Li WS, Liu FK, Yao XQ, Li G. Insulin-like growth factor receptor-1 overexpression is associated with poor response of rectal cancers to radiotherapy. World J Gastroenterol 2014; 20(43): 16268-16274 [PMID: 25473182 DOI: 10.3748/wjg.v20.i43.16268]

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