Targeted migration of mesenchymal stem cells modified with CXCR4 to acute failing liver improves liver regeneration

Figure 4 Transplantation of chemokine CXC receptor 4-mesenchymal stem cells or Null-mesenchymal stem cells improved survival rate and histopathological recovery, and inhibited liver enzyme release in acute liver failure. A: Survival analysis of CCl₄-treated nude mice; B: HE staining: normal liver tissue; acute liver failure (ALF) mice showed typical histology with extensive hepatocyte necrosis and hemorrhage involving entire lobules; ALF mice transplanted with Null-mesenchymal stem cells (MSCs); ALF mice transplanted with chemokine CXC receptor 4 (CXCR4)-MSCs; C: Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) enzyme levels in peripheral blood samples collected at 7 d after transplantation. ^aP < 0.05 vs phosphate-buffered saline (PBS) group; ^cP < 0.05 vs Null group, data are shown as mean ± SD.