Review
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Oct 28, 2014; 20(40): 14805-14820
Published online Oct 28, 2014. doi: 10.3748/wjg.v20.i40.14805
Table 2 Main case series and reports of fecal microbiota transplantation in inflammatory bowel disease treatment
Ref.IBD type (n)StoolmaterialVolumeinfusionInfusion routeFrequencyDonor relationshipCharacteristics of outcomes
Bennet et al[34], 1989UC (1)NRNREnema1NRDocuments remission for 6 mo and cease medications
Borody et al[144], 1989UC (1)NRNREnemaNRNRDocumented remission for 3 mo and cease medications.
Borody et al[35], 2003UC (6)Fresh200-300 g/200-300 mLEnema6Related or unrelatedDocumented remission from 1 to 13 yr and cease medications
Hamilton et al[112], 2012UC combinedwith CDI (4)Fresh orfrozen220-240 mLColonoscopy1Related or unrelatedColitis activity was improved, and CDI was cured
Zainah et al[145], 2012UC combined with CDI (1)Fresh300 mLColonoscopy1RelatedDocumented symptom-free for 8 mo without CDI recurrence
Borody et al[146], 2012UC (3)FreshNRRepeated rectal infusionsDaily infusion for 2 to 6.5 moRelated or unrelatedDocumented improvement from 1 to 36 mo
Patel et al[147], 2013UC combined with CDI (3)Fresh18-397 g/180-600 mLColonoscopy1Related or unrelatedSymptoms such as diarrhea improved or resolved 3 mo after FMT
Angelberger et al[105], 2013UC (5)Fresh17-25 g/250 mL +6-12 g/100 mLNasojejunal tube + enema3UnrelatedNone of cases achieved remission, but only one case was response to FMT by week 12; two cases deteriorated 4 wk after FMT
Kump et al[148], 2013UC (6)Fresh300-500 mLColonoscopy1UnrelatedDocumented improvement, but no remission within 2 wk after FMT
De Leon et al[110], 2013UC combined with CDI (1)Fresh600 mLColonoscopy1RelatedUC relapse 9 d after FMT
Kunde et al[108], 2013UC (10)Fresh165 mlEnema5Related78% and 67% subjects achieved clinical response within 1 wk and 1 mo after FMT, respectively
Borody et al[144], 1989CD (1)NRNREnemaNRNRSymptoms-free and receiving no medications 4 mo after FMT
Grehan et al[118], 2010CD (1)Fresh200-400 mLColonoscopy + enema1 + 9NRCD related improvement was not reported
Hamilton et al[112], 2012CD combined with CDI (6)Fresh orfrozen220-240 mLColonoscopy1 or 2Related or unrelatedTwo cases accepted the second FMT due to CDI recurrence, but the efficacy of FMT on CD was not reported
Patel et al[147], 2013CD combined with CDI (2)Fresh18-397 g/180-600 mLColonoscopyUpper endoscopy2Related or unrelatedCDI recurred in 1 case after the first FMT by colonoscopy, and a second FMT was performed by upper endoscopy; but the efficacy of FMT on CD was not reported
Gordon et al[109], 2013CD (1)FreshNRNRNRRelatedResponse to FMT for 6 mo and then relapsed
Quera et al[149], 2013CD combined with CDI (1)NRNRColonscopyNRNRTransient bacteremia occurred 24 h after FMTDocumented symptom-free 5 mo after FMT and CDI disappeared
Zhang et al[36], 2013CD (1)Fresh150 mLGastroscope1RelatedDocumented clinical remission for more than 9 mo