Clinical management of advanced gastric cancer: The role of new molecular drugs

doi:10.3748/wjg.v20.i40.14537

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 20, Issue 40

This Article

Academic Content and Language Evaluation of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (11225)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Tables (1-5) series.

Item

Count

PDF

673

WORD

340

HTML

7409

Tables (1-5)

129

Sum=8551

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1474

Download

1200

Sum=2674

Oct 28, 2014 (publication date) through Apr 24, 2024

Times Cited of This Article

Times Cited (35)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Topic Highlight

World J Gastroenterol. Oct 28, 2014; 20(40): 14537-14558
Published online Oct 28, 2014. doi: 10.3748/wjg.v20.i40.14537

Table 1 Phase II/III trials with anti vascular-endothelial growth factor agents for advanced gastric cancer and gastro-esophageal junction cancers

Trial	Phase	Setting	Regimen	Patients (n)	RR	OS (mo)	TTP/PFS (mo)
NCT00084604[49], 2006	II	1^st line	Iri + C + Bev	47	65%	12.3	8.3
NCT00217581[50], 2010	II	1^st line	DOCOX + Bev	38	59%	11.1	6.6¹
	II	1^st line	DOCOX + Bev	38	59%	11.1	6.6¹
AVAGAST[51,54], 2010	III	1^st line	XC + Bev	387	46%	12.1	6.7
	III	1^st line	XC + Placebo	387	37.4%	10.1	5.3
ST03[55], 2012	II/III	Perioperative	ECX-B	200	-	-	-
	II/III	Perioperative	ECX-B	200	-	-	-
REGARD[58], 2012	III	2^nd line	Ram + BSC	235	-	5.2	2.1¹
	III	2^nd line	BSC	117	-	3.8	1.7¹
RAINBOW[60], 2014	III	2^nd line	PTX + Ram	665	28%	9.6	4.4
	III	2^nd line	PTX + placebo	665	28%	9.6	4.4
ECOG 5203[63], 2010	II	1^st line	TXT + C + Sor	44	39%	13.6	5.8
	II	1^st line	TXT + C + Sor	44	39%	13.6	5.8
NCT01262482[64], 2012	II	2^nd line	Sor + O	40	-	6.5	3.0¹
	II	2^nd line	Sor + O	40	-	6.5	3.0¹
NCT00411151[67], 2011	II	2^nd line	Sun	52	3.9%	5.81	1.28¹
	II	2^nd line	Sun	52	3.9%	5.81	1.28¹
NCT00226811[68], 2011	II	2^nd line	Sun	78	2.6%	6.8	2.3
	II	2^nd line	Sun	78	2.6%	6.8	2.3
NCT00970138[73], 2011	II	3^rd line	A: Placebo		-	2.5	1.4¹
			B: Apa (850 mg)		-	4.83	3.67¹
			C: Apa (425 mg bid)	144		4.27	3.2¹
NCT01512745[74], 2012	III	3^rd line	Apa	-	-	-	-
NCT01512745[74], 2012	III	3^rd line	Placebo	-	-	-	-
TEL0805 trial[75], 2011	II	1^st line	XC + Tel	39	6.7%	-	-

¹Progression free survival (PFS). Iri: Irinotecan; Cis: Cisplatin; Bev: Bevacizumab; X: Capecitabine; C: Cisplatin; E: Epirubicin; Ram: Ramucirumab; PTX: Paclitaxel; Sor: Sorafenib; Sun: Sunitinib; Apa: Apatinib; Tel: Telantinib; DOCOX: Docetaxel plus oxaliplatin; O: Oxaliplatin; TXT: Docetaxel; BSC: Best supportive care; RR: Response rate; OS: Overall survival; TTP/PFS: Time to progression/progression free survival.

Citation: Vita FD, Martino ND, Fabozzi A, Laterza MM, Ventriglia J, Savastano B, Petrillo A, Gambardella V, Sforza V, Marano L, Auricchio A, Galizia G, Ciardiello F, Orditura M. Clinical management of advanced gastric cancer: The role of new molecular drugs. World J Gastroenterol 2014; 20(40): 14537-14558
URL: https://www.wjgnet.com/1007-9327/full/v20/i40/14537.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i40.14537