Fecal immunochemical test accuracy in average-risk colorectal cancer screening

Table 2 Performance characteristics of fecal immunochemical test-1 and -max for advanced neoplasia¹ detection at different thresholds

Hemoglobin concentration (ng/mL)	FIT strategy	Individuals with a positive result2	Sensitivity3	P4	Specificity3	P5	Positive predictive value3	Negative predictive value3	Positive likelihood ratio3	Negative likelihood ratio3
50	FIT16	67 (8.6)	35 (25-45)	0.06	95 (93-97)	0.001	51 (38-63)	91 (89-93)	7.24 (4.72-11.13)	0.68 (0.59-0.79)
	FITmax7	101 (13.0)	42 (32-53)	0.03	91 (89-93)	< 0.001	41 (31-51)	92 (90-94)	4.98 (3.44-6.72)	0.63 (0.53-0.75)
75	FIT16	61 (7.8)	33 (23-43)	0.2	96 (94-97)	0.01	52 (39-66)	91 (89-93)	7.76 (4.92-12.23)	0.70 (0.61-081)
	FITmax7	89 (11.4)	40 (30-51)	0.1	93 (91-95)	0.03	44 (33-55)	92 (89-94)	5.48 (3.82-7.87)	0.65 (0.55-0.76)
100	FIT16	55 (7.1)	32 (22-42)	0.5	96 (95-98)	0.5	56 (42-70)	91 (89-93)	9.08 (5.57-14.80)	0.71 (0.61-0.81)
	FITmax7	82 (10.5)	37 (27-47)	1	93 (91-95)	0.5	44 (33-55)	91 (89-93)	5.50 (3.76-8.05)	0.67 (0.58-0.79)
115	FIT16	51 (6.5)	30 (20-40)		97 (95-98)		57 (42-71)	91 (88-93)	9.27 (5.56-15.46)	0.72 (0.64-0.83)
	FITmax7	79 (10.1)	36 (26-46)		94 (92-95)		44 (33-56)	91 (89-93)	5.59 (3.79-8.26)	0.68 (0.59-0.79)
150	FIT16	48 (6.2)	28 (18-37)	0.5	97 (96-98)	1	56 (41-71)	90 (88-93)	9.04 (5.33-15.34)	0.74 (0.66-0.84)
	FITmax7	70 (9.0)	32 (22-42)	0.1	94 (92-96)	0.06	44 (32-57)	91 (88-93)	5.59 (3.67-8.51)	0.72 (0.63-0.83)
200	FIT16	45 (5.8)	28 (18-37)	0.5	97 (96-99)	0.1	60 (44-75)	90 (88-93)	10.55 (6.04-18.41)	0.74 (0.65-0.84)
	FITmax7	59 (7.6)	28 (18-37)	0.08	95 (94-97)	< 0.001	46 (32-59)	90 (88-93)	5.93 (3.72-9.45)	0.76 (0.67-0.86)

¹Advanced neoplasia: advanced adenomas (adenoma > 1 cm in size, with high-grade dysplasia, or with villous component > 25) or colorectal cancer;

²Values are expressed as absolute numbers and percentage;

³Values are expressed as percentage and its 95%CI; ⁴Significance of the sensitivity differences when compared with the optimal cut-off point in McNemar test. Differences with P < 0.05 are considered statistically significant; ⁵Significance of the specificity differences when compared with the optimal cut-off point in McNemar test. Differences with P < 0.05 are considered statistically significant;

⁶Fecal hemoglobin concentration in the first sample;

⁷Higher fecal hemoglobin concentration of the two samples. FIT: Fecal immunochemical test.