Meta-Analysis
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Sep 21, 2014; 20(35): 12637-12648
Published online Sep 21, 2014. doi: 10.3748/wjg.v20.i35.12637
Table 4 Studies on matrix metalloproteinase inhibitors in colonic anastomotic healing
StudyCompoundSpeciesSexSample size1Dosage (mg/kg)RouteTestTest dayEffect2
de Hingh et al[79]BB-94RatMale6030IPBPR/BST1NS/NS
BPR/BST3↑54/↑27
BPR/BST7NS/NS
Kiyama et al[80]BE16627BRatMale21About 10SCBPR4↑28
Pasternak et al[81]DoxycyclineRatMale40NALOBST3↑17
Siemonsma et al[82]DoxycyclineRatMale80About 40SCBPR/BST1NS/NS
SCBPR/BST3↑93/↑27
POBPR/BST3↑36/NS
SCBPR/BST5NS/NS
Syk et al[7]BB-1101RatMale4830SCBST1/3/7NS/↑48/NS
Ågren et al[8]AG3340RatMale12010SCBST3↑47
GM6001RatMale10/100SCBST3↑79/↑88