Occupational exposures and colorectal cancers: A quantitative overview of epidemiological evidence

Table 3 Pooled estimates for colon cancer, by industrial branch and study design

ISIC	Industrial branch	Cohort studies		Other study design2		All
		(95%CI)		(95%CI)		(95%CI)
		Crude RR	Adjusted RR3	Crude RR	Adjusted RR3	Crude RR	Adjusted RR3
1	Crop and animal production	1	-	0.98	-	0.96	-
		(0.66-1.52)		(0.85-1.13)		(0.84-1.10)
2	Forestry and logging1	-	-	1.48	-	1.48	-
				(0.28-7.92)		(0.28-7.92)
3	Fishing and aquaculture1	0.93	-	-	-	0.93	-
		(0.79-1.09)				(0.79-1.09)
5	Mining of coal and lignite	0.9	-	1.1	-	0.92	0.9
		(0.68-1.20)		(0.42-2.91)		(0.69-1.21)	(0.69-1.17)
7	Mining of metals	0.19	-	1.5	-	0.57	-
		(0.05-0.71)		(0.65-3.64)		(0.08-4.30)
8	Other mining and quarrying1	-	-	0.91	-	0.91	-
				(0.45-1.83)		(0.45-1.83)
10	Manufacture of food products	1.06	-	1.32	-	1.28	-
		(0.44-2.57)		(0.93-1.87)		(0.98-1.70)
11	Manufacture of beverages	1.25	-	-	-	1.25	-
		(1.12-1.40)				(1.12-1.40)
14	Manufacture of wearing apparel1	-	-	0.66	-	0.66	-
				(0.20-2.20)		(0.20-2.20)
15	Manufacture of leather and related products	1.66	-	1.3	-	1.49	1.49
		(0.85-3.24)		(0.61-2.76)		(0.90-2.46)	(0.90-2.46)
16	Manufacture of wood and of products of wood and cork	2.19	1.2	0.53	-	0.96	0.96
		(0.56-8.52)	(0.35-4.16)	(0.37-0.78)		(0.46-1.97)	(0.46-1.97)
17	Manufacture of paper and paper products1	-	-	0.66	-	0.66	-
				(0.17-2.61)		(0.17-2.61)
18	Printing and reproduction of recorded media1	-	-	1.8	-	1.8	-
				(1.20-2.70)		(1.20-2.70)
19	Manufacture of coke and refined petroleum products1	-	-	1.3	-	1.3	-
				(0.51-3.29)		(0.51-3.29)
20	Manufacture of chemicals and chemical products	1.2	-	1.07	-	1.18	-
		(0.99-1.45)		(0.68-1.71)		(0.99-1.40)
21	Manufacture of basic pharmaceutical products and pharmaceutical preparations1	1.22	-	-	-	1.22	-
		(0.58-2.24)				(0.58-2.24)
22	Manufacture of rubber and plastics products	1.31	-	1.16	-	1.19	1.16
		(0.88-1.95)		(0.95-1.41)		(1.00-1.42)	(0.99-1.36)
23	Manufacture of other non-metallic mineral products1	0.77	-	-	-	0.77	-
		(0.29-2.06)				(0.29-2.06)
24	Manufacture of basic metals	1.75	1.61	-	-	1.75	1.61
		(1.16-2.65)	(1.09-2.38)			(1.16-2.65)	(1.09-2.38)
25	Manufacture of fabricated metal products	-	-	0.83	-	0.83	-
				(0.55-1.24)		(0.55-1.24)
31	Manufacture of furniture	1.65	-	0.8	-	1.4	-
		(1.24-2.20)		(0.27-2.36)		(0.77-2.54)
33	Repair and installation of machinery and equipment	1.91	1.81	0.99	-	1.75	-
		(1.39-2.62)	(1.39-2.37)	(0.43-2.29)		(1.27-2.41)
49	Land transport1	-	-	2.39	-	2.39	-
				(0.83-6.92)		(0.83-6.92)
72	Scientific research and development1	1.23	-	-	-	1.23	-
		(0.72-2.11)				(0.72-2.11)
84	Public administration and defence	1.32	-	0.9	-	1.19	-
		(0.85-2.05)		(0.59-1.38)		(0.85-1.67)
86	Human health activities1	-	-	1	-	1	-
				(0.49-2.05)		(0.49-2.05)
96	Other personal service activities1	-	-	1.37	-	1.37	-
				(0.51-3.72)		(0.51-3.72)
-	All industrial branches combined	1.23	1.23	1.03	1.03	1.13	1.13
		(1.09-1.39)	(1.09-1.39)	(0.92-1.15)	(0.92-1.15)	(1.05-1.22)	(1.05-1.22)
	Heterogeneity (I2)	70.5%		42.3%		61.4%

¹Only one study;

²Case-control studies and meta-analyses;

³Duval and Tweedie trim and fill method. RR: Relative risk; ISIC: International Standard Industrial Classification.