Cell-type specificity of &beta;-actin expression and its clinicopathological correlation in gastric adenocarcinoma

doi:10.3748/wjg.v20.i34.12202

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Evidence-Based Medicine

World J Gastroenterol. Sep 14, 2014; 20(34): 12202-12211
Published online Sep 14, 2014. doi: 10.3748/wjg.v20.i34.12202

Table 3 Univariate analysis of β-actin immunostaining with clinicopathological parameters n (%)

Clinicopathological parameters	Groups		Epithelial cells (total IHC score)	Inflammatory cells (total IHC score)	Epithelial + Inflammatory cells (avg. total IHC score)
Clinicopathological parameters	Groups		P value	P value	P value
Age (yr)
	≤ 50	11 (42)	0.4933¹	0.2724¹	0.2941¹
	> 50	15 (58)	0.4933¹	0.2724¹	0.2941¹
Sex
	Male	20 (77)	0.9721¹	0.2724¹	0.5275¹
	Female	6 (23)	0.9721¹	0.2724¹	0.5275¹
Tumor grade
	WD	0 (0)	0.6089²	0.0168²	0.8393²
	MD	4 (15)
	PD	14 (54)
	Mucinous	0 (0)
	SRC	8 (31)
Depth of invasion³
	T1	2 (8)	0.5446²	0.6618²	0.8804²
	T2	2 (8)
	T3	13 (52)
	T4	8 (32)
Lymph Node status³
	N0	6 (24)	0.7510²	0.6293²	0.5426²
	N1	8 (32)
	N2	8 (32)
	N3	3 (12)
Treatment Modality³
	Surgery	14 (56)	0.3542¹	0.8135¹	0.2910¹
	NACT + surgery	11 (44)	0.3542¹	0.8135¹	0.2910¹

¹Mann Whitney Test;

²Kruskal Wallis Test;

³TNM staging and Treatment modality information was available for only 25 (out of 26) patients. P < 0.05 indicates statistically significant difference. IHC: Immunohistochemistry; MD: Moderately differentiated; PD: Poorly differentiated; SRC: Signet ring cell carcinoma.

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Citation: Khan SA, Tyagi M, Sharma AK, Barreto SG, Sirohi B, Ramadwar M, Shrikhande SV, Gupta S. Cell-type specificity of β-actin expression and its clinicopathological correlation in gastric adenocarcinoma. World J Gastroenterol 2014; 20(34): 12202-12211
URL: https://www.wjgnet.com/1007-9327/full/v20/i34/12202.htm
DOI: https://dx.doi.org/10.3748/wjg.v20.i34.12202

Khan SA, Tyagi M, Sharma AK, Barreto SG, Sirohi B, Ramadwar M, Shrikhande SV, Gupta S. Cell-type specificity of β-actin expression and its clinicopathological correlation in gastric adenocarcinoma. World J Gastroenterol 2014; 20(34): 12202-12211 [PMID: 25232253 DOI: 10.3748/wjg.v20.i34.12202]

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