Early detection and prevention of pancreatic cancer: Is it really possible today?

Table 5 Summary of diagnostic yield of familial pancreatic cancer screening

Ref.	Year	Syndrome(s)	Patients (n)	Yield
Brentnall et al[106]	1999	FPC	14	50%
Kimmey et al[107]	2002	FPC	46	26%
Poley et al[108]	2009	FPC, PJS, BRCA, p16, p53, HP	44	23%
Langer et al[109]	2009	FPC, BRCA	76	1.3%
Verna et al[110]	2010	FPC, BRCA, p16	51	12%
Ludwig et al[111]	2011	FPC, BRCA	109	8.3%
Vasen et al[112]	2011	P16	79	18%
Al-Sukhni et al[113]	2011	FPC, BRCA, PJS, p16, HP	262	7.3%
Schneider et al[114]	2011	FPC, BRCA, PALB2	72	15%
Canto et al[115]	2012	FPC, BRCA, PJS	216	43%

HP: Hereditary pancreatitis; FPC: Familial pancreatic cancer; PJS: Peutz-Jeghers syndrome; BRCA: Breast cancer.