MicroRNAs as potential biomarkers for gastric cancer

Table 4 Circulating microRNAs as prognostic biomarkers

Ref.	Sample	Method (normalization)	MiRNA	Clinical application
Valladares-Ayerbes et al[81] (ES)	52 GC/31 C peripheral blood and 2 GC cell lines	qRT-PCR (U6, 5S)	miR-200c	Predictor of progression and survival
Komatsu et al[78] (JP)	69 GC plasma	qRT-PCR (U6)	miR-21	Prognostic marker
Wang et al[79] (CN)	79 pre-operative GC/30 post-/6 relapse plasma	qRT-PCR (RNU6B)	miR-17-5p/20a	Prediction of prognosis and monitoring of chemotherapeutic effects
Kim et al[80] (KR)	16 LN-positive GC/15 LN-negative GC/10 C serum	qRT-PCR	miR-21, miR-146a, and miR-148a	Predicting LN metastasis

C: Control; GC: Gastric cancer; LN: Lymph node.