MicroRNAs as potential biomarkers for gastric cancer

Table 1 Tissue microRNAs as diagnostic biomarkers

Ref.	Sample	Method (normalization)	MiRNA	Clinical application
Jiang et al[60] (CN)	60 GC (46A, 6M, 8S)/18 C	qRT-PCR (U6)	miR-421	Diagnostic biomarker
Zhang et al[59] (CN)	63 GC/10 C	real-time qRT-PCR (RNU6B)	miR-31	Diagnostic biomarker
Xiao et al[53] (CN)	55 GC/17 C	real-time qRT-PCR (U6)	miR-106a	Diagnostic biomarker
Chan et al[58] (CN)	37 GC/37 C	qPCR (U6)	miR-21	Diagnostic marker
Tsai et al[67] (CN)	72 GC/72 C	qRT-PCR	miR-196a	Detecting GC and monitoring recurrence
Xiao et al[98] (CN)	20 GC/20 C	qRT-PCR (U6)	miR-146a	Diagnostic biomarker and therapeutic target
Song et al[50] (CN)	4 GC cell lines	real-time qRT-PCR (U6)	miR-148b	Diagnostic biomarker
	106 GC/106 C tissues
Chen et al[51] (CN)	101 GC(34I, 67B)/101CC/101 C	real-time qRT-PCR (U6)	miR-148a and miR-152	Detection of gastrointestinal cancer
Su et al[101] (CN)	20 GC/20 C	miRNA microarray and qRT-PCR (U6)	miR-574-3p	Early detection of GC

C: Control; GC: Gastric cancer; A: Adenocarcinoma; M: Mucinous carcinoma; S: Signet-ring cell carcinoma; I: Intestinal; D: Diffuse.