Pancreatic enzyme replacement therapy for pancreatic exocrine insufficiency in the 21st century

Figure 10 Box plot showing median and 25% and 75% and range for a randomized cross-over study comparing the effect of 1200 mg cimetidine or 60 mg of omeprazole on the effectiveness of pancreatic enzymes. Six tablets of unprotected enzymes (Cotazyme Forte^® 36000 FIP units/meal) given 1/2 before meal and 1/2 during the meal). Both antisecretory agents improved outcome but neither reliably resolved steatorrhea. Data from[72].