Pancreatic enzyme replacement therapy for pancreatic exocrine insufficiency in the 21st century

Figure 9 Randomized cross-over comparison of similar amounts of lipase administered as unprotected capsule (Cotazyme^®) or enteric coated microspheres (Pancrease^®) in cystic fibrosis patients with pancreatic insufficiency. Although the enteric coated preparation was better in those with the greatest degree of malabsorption, neither resulted in resolution of steatorrhea[61].