Advances in the management of peritoneal mesothelioma

Table 2 Prognostic factors in cytoreduction and hyperthermic intraperitoneal chemotherapy procedures

Ref.	Year	Sample No.	Prognostic factors overall survival (multivariate only)
Deraco et al[38]	2003	61	Completeness of cytoreduction
Feldman et al[48]	2003	49	1No prior debulking, deep invasion, age > 60, residual disease > 1 cm
Nonaka et al[51]	2005	35	Completeness of cytoreduction, low mitotic count, lower nuclear grade
Deraco et al[40]	2006	49	Completeness of cytoreduction, low mitotic count/50 HPF
Yan et al[45]	2006	100	No lymph node metastasis, female gender, epithelial type, adequate cytoreduction
Baratti et al[20]	2007	60	1High-grade histology, WHO performance status > 0, Inadequate cytoreduction
Yan et al[41]	2007	62	Mesothelioma nuclear size
Yan et al[42]	2009	401	Epithelial subtype, absence of lymph node metastasis, completeness of cytoreduction 0/1, HIPEC
Baratti et al[35]	2010	83	Pathologically negative lymph nodes, epithelial subtype, mitotic count ≤ 5/50 HPF, Completeness of cytoreduction
Kluger et al[54]	2010	47	1Biphasic histological subtype
Yan et al[43]	2011	294	1Biphasic/sarcomatoid subtype, completeness of cytoreduction score of 2/3, proposed TNM Stage II or III
Cao et al[46]	2012	294	Female gender, TNM staging
Baratti et al[53]	2012	60	Complete parietal peritonectomy, complete cytoreduction, negative lymph nodes, Epithelial histology, low MIB-1 index
Alexander et al[47]	2013	211	Age < 60 yr, R0-1 vs R2-3, low histologic grade, use of cisplatin vs mitomycin-C
Baratti et al[34]	2013	108	Epithelial histology, histologically negative lymph nodes, Ki-67 < 10%
Deraco et al[50]	2013	116	Histological subtype, completeness of cytoreduction, absence of morbidity 3-5 grade
Schaub et al[59]	2013	104	Histological subtype, pre-CRS PCI, preoperative serum CA-125
Wong et al[52]	2013	29	Lower peritoneal carcinoma index, completeness of cytoreduction
Pillai et al[58]	2013	33	Presence of nuclear estrogen receptor beta

¹Variables that have negatively impacted overall survival.